Article

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma

2023-04-17

Abstract excerpt

Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic pontine glioma – DIPG), are uniformly fatal brain tumors that lack effective pharmacological treatment. Analysis of pooled CRISPR-Cas9 loss-of-function gene deletion screen datasets, identified PIK3CA and MTOR as targetable molecular dependencies across DIPG patient derived models, highlighting the therapeutic potential...

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Literature Corpus work: 6867e199-7e5b-5721-abb1-8771f8141da4
DOI: 10.1101/2023.04.17.537256

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