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Article

mTOR signaling in glioblastoma: lessons learned from bench to bedside

14 May 2010

Abstract excerpt

Phosphatidyl-inositol-3 kinases (PI3Ks) constitute a family of intracellular lipid kinases that are frequently hyperactivated in glioblastoma. The PI3K complex links growth factor signaling with cellular proliferation, differentiation, metabolism, and survival. Mammalian target of rapamycin (mTOR) acts both as a downstream effector and upstream regulator of PI3K, thus highlighting its importance in glioblastoma....

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PMID: 20472883
DOI: 10.1093/neuonc/noq052

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