Article
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Cancer research - 15 Apr 2005
Wislez Marie, Spencer M Loreto, Izzo Julie G, Juroske Denise M, Balhara Kamna, Cody Dianna D, Price Roger E, Hittelman Walter N, Wistuba Ignacio I, Kurie Jonathan M
Abstract excerpt
The serine/threonine kinase AKT and its downstream mediator mammalian target of rapamycin (mTOR) are activated in lung adenocarcinoma, and clinical trials are under way to test whether inhibition of mTOR is useful in treating lung cancer. Here, we report that mTOR inhibition blocked malignant progression in K-ras(LA1) mice, which undergo somatic activation of the K-ras oncogene and display morphologic changes in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.