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Article

Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer.

Oncoimmunology - 1 Jan 2023

Sandström Gerdtsson Anna, Knulst Mattis, Botling Johan, Mezheyeuski Artur, Micke Patrick, Ek Sara

Abstract excerpt

The immune microenvironment of non-small cell lung cancer (NSCLC) is heterogeneous, which impedes the prediction of response to immune checkpoint inhibitors. We have mapped the expression of 49 proteins to spatial immune niches in 33 NSCLC tumors and report key differences in phenotype and function associated with the spatial context of immune infiltration. Tumor-infiltrating leukocytes (TIL), identified in 42%...

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Source

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Identifiers

PMID: 37139184
DOI: 10.1080/2162402X.2023.2206725
PMCID: PMC10150622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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