Article

Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response

2023-04-06

Abstract excerpt

<h4>ABSTRACT</h4> The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially-localized multicellular ‘immunity hubs’ defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we examined immunity hubs in human pre-immunotherapy lung cancer specimens, and found that they were associated with beneficial responses to PD-1-bl...

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Literature Corpus work: 7b0ebcfa-a4c7-5dc2-94fb-4431c0889755
DOI: 10.1101/2023.04.04.535379

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