Article
The relationship between serotonin transporter occupancy and extracellular serotonin concentration is hyperbolic, not linear: implications for safely tapering antidepressants
2026-06-18
Abstract excerpt
<h4>Background</h4> Hyperbolic tapering is an increasingly recognized approach for discontinuing serotonin reuptake inhibitor (SRI) antidepressants that involves non-linear dose reductions with equal stepwise reductions in serotonin transporter (SERT) occupancy to mitigate withdrawal symptoms. Its theoretical basis is the hyperbolic relationship between SRI dose and SERT occupancy reported in radioligand imaging...
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Identifiers and source
- Literature Corpus work
- 61b01a17-d3d5-5bac-a331-4ef2e559b212
- DOI
- 10.64898/2026.06.09.26355019