Article

Standardization of lithium concentration to the 12-hour level using SimpLi: a simulation study and model validation

2026-02-06

Abstract excerpt

<h4>Background</h4> Lithium is one of the key medications for the treatment of bipolar disorder, but it requires therapeutic drug monitoring because of its narrow therapeutic window. In routine clinical practice, blood sampling is often performed outside the recommended 10–14 hour interval after the last evening dose, which distorts interpretation of the measured concentration (overestimation with early sampling...

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Literature Corpus work: 84bb940d-5b85-5cbe-9a3a-4678736a5980
DOI: 10.64898/2026.01.29.26344876

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