Article

Rebound activation of 5-HT neurons following SSRI discontinuation

2023-09-23

Abstract excerpt

Cessation of therapy with a selective serotonin (5-HT) reuptake inhibitor (SSRI) is often associated with an early onset, disabling discontinuation syndrome the mechanism of which is surprisingly little investigated. Here we determined the effect on 5-HT neurochemistry of discontinuation from the SSRI paroxetine. Paroxetine was administered repeatedly to mice (once daily, 12 days versus saline controls) and then e...

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Literature Corpus work: 00311749-a127-5214-8da1-5e257c641f34
DOI: 10.1101/2023.09.23.558888

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