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Network pharmacology and experimental validation of andrographolide’s renoprotective effects on diabetic nephropathy via AGEs-RAGE signaling and mitophagy pathways

2024-07-12

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<title>Abstract</title> <p>Diabetic nephropathy (DN) is a severe diabetic complication, manifested by glomerulosclerosis, renal interstitial fibrosis and inflammation. Andrographolide (AD) is a natural compound with multiple pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, etc. However, the mechanism of AD on DN remains elusive. In this study, we integrated network pharmacology and i...

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Literature Corpus work
3bd587e5-af47-58af-9651-ebc57419e248
DOI
10.21203/rs.3.rs-4621164/v1
Open publication

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Network pharmacology and experimental validation of andrographolide’s renoprotective effects on diabetic nephropathy via AGEs-RAGE signaling and mitophagy pathwaysDOI 10.21203/rs.3.rs-4621164/v1
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