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Article

A Rare Kidney Disease To Cure Them All? Towards Mechanism-Based Therapies for Proteinopathies.

Trends in molecular medicine - 1 Apr 2021

Dvela-Levitt Moran, Shaw Jillian L, Greka Anna

Abstract excerpt

Autosomal dominant tubulointerstitial kidney diseases (ADTKDs) are a group of rare genetic diseases that lead to kidney failure. Mutations in the MUC1 gene cause ADTKD-MUC1 (MUC1 kidney disease, MKD), a disorder with no available therapies. Recent studies have identified the molecular and cellular mechanisms that drive MKD disease pathogenesis. Armed with patient-derived cell lines and pluripotent stem cell...

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Identifiers

PMID: 33341352
DOI: 10.1016/j.molmed.2020.11.008

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