Article

Fast Bayesian Inference of Copy Number Variants using Hidden Markov Models with Wavelet Compression

2015-07-31

Abstract excerpt

By combining Haar wavelets with Bayesian Hidden Markov Models, we improve detection of genomic copy number variants (CNV) in array CGH experiments compared to the state-of-the-art, including standard Gibbs sampling. At the same time, we achieve drastically reduced running times, as the method concentrates computational effort on chromosomal segments which are difficult to call, by dynamically and adaptively recomp...

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Literature Corpus work: 61a0c576-e179-5db7-b1db-58945e3a5f35
DOI: 10.1101/023705

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