Article
The survival motor neuron gene smn-1 interacts with the U2AF large subunit gene uaf-1 to regulate Caenorhabditis elegans lifespan and motor functions.
RNA biology - 1 Jan 2014
Gao Xiaoyang, Teng Yanling, Luo Jintao, Huang Liange, Li Min, Zhang Zhuohua, Ma Yong-Chao, Ma Long
Abstract excerpt
Spinal muscular atrophy (SMA), the most frequent human congenital motor neuron degenerative disease, is caused by loss-of-function mutations in the highly conserved survival motor neuron gene SMN1. Mutations in SMN could affect several molecular processes, among which aberrant pre-mRNA splicing caused by defective snRNP biogenesis is hypothesized as a major cause of SMA. To date little is known about the...
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