Article

Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing

2021-04-14

Abstract excerpt

<title>Abstract</title> <p>Silencing of a subset of germline genes is dependent upon DNA methylation (DNAme) post-implantation. However, these genes are generally hypomethylated in the ICM, implicating alternative silencing pathways before implantation. Indeed, in embryonic stem cells (ESCs), an overlapping set of genes, including germline “genome-defence” (GGD) genes, are upregulated following deletion of the H3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 616a4c47-1a7d-5a1a-b818-06271358037e
DOI: 10.21203/rs.3.rs-400263/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencingDOI 10.21203/rs.3.rs-400263/v1Read

Preventing CpG island hypermethylation in oocytes safeguards mouse developmentSemantic proximity Read

Insights into epigenetic patterns in mammalian early embryosSemantic proximity Read

Conserved enhancer association of piRNAs and the implication in germ cell fate surveillanceSemantic proximity Read

The <i>Drosophila</i> histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiationSemantic proximity Read

A survey of human cancer-germline genes: linking X chromosome localization, DNA methylation and sex-biased expression in early embryosSemantic proximity Read

Germline chromatinSemantic proximity Read

Loss of maternal Trim28 causes male-predominant early embryonic lethality.Semantic proximity Read

Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissuesSemantic proximity Read

Germline-derived DNA methylation and early embryo epigenetic reprogramming: The selected survival of imprintsSemantic proximity Read

Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo.Semantic proximity Read

Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cellsSemantic proximity Read

Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation ProtectionSemantic proximity Read