Article

<i>KCNMA1</i> -linked channelopathy

2019-08-19

Abstract excerpt

KCNMA1 encodes the pore-forming α subunit of the ‘Big K + ’ (BK) large conductance calcium and voltage-activated K + channel. BK channels are widely distributed across tissues, including both excitable and non-excitable cells. Expression levels are highest in brain and muscle, where BK channels are critical regulators of neuronal excitability and muscle contractility. A global deletion in mouse ( KCNMA1 –/– )...

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Literature Corpus work: 545ecfe4-65bb-5fb2-a326-89201805dc3e
DOI: 10.7287/peerj.preprints.27876v3

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