Article

Sulforaphane Inhibits Self-renewal of Lung Cancer Stem Cells Through the Modulation of Polyhomeotic Homolog 3 and Sonic Hedgehog Signaling Pathways

2019-08-03

Abstract excerpt

<h4>Background: </h4> Sulforaphane (SFN), an active compound in cruciferous vegetables has been characterized for its antiproliferative capacity. We investigated the role and molecular mechanism through which SFN regulates proliferation and self-renewal of lung cancer stem cells. <h4>Methods:</h4> Lung cancer stem cells (CD133-positive cells) were isolated by MACs and then measured by flow cytometry. The ability o...

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Literature Corpus work: 613cb7e6-54ec-597d-890c-0d9b55c49dd0
DOI: 10.21203/rs.2.11459/v1

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