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Article

PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells

1 Jan 2025

Abstract excerpt

Small cell lung cancer (SCLC) is a highly aggressive form of lung cancer. The aberrant regulation of Paired box 6 (PAX6) expression has been proposed to play an important oncogenic role in several cancer types. Nevertheless, there is limited knowledge regarding its function in SCLC. Here, we find that PAX6 overexpression promotes SCLC cell proliferation and cell cycle progression, while downregulation of PAX6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39885876
DOI: 10.1016/j.heliyon.2025.e41795

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