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Emerging agents that target signaling pathways in cancer stem cells

26 May 2020

Abstract excerpt

Cancer stem cells (CSCs) contribute to the initiation, recurrence, and metastasis of cancer; however, there are still no drugs targeting CSCs in clinical application. There are several signaling pathways playing critical roles in CSC progression, such as the Wnt, Hedgehog, Notch, Hippo, and autophagy signaling pathways. Additionally, targeting the ferroptosis signaling pathway was recently shown to specifically...

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PMID: 32456660
DOI: 10.1186/s13045-020-00901-6

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