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Article

Association Analysis of PRSS1-PRSS2 and CLDN2-MORC4 Variants in Nonalcoholic Chronic Pancreatitis Using Tropical Calcific Pancreatitis as Model.

Pancreas - 1 Sept 2016

Paliwal Sumit, Bhaskar Seema, Nageshwar Reddy D, Rao G Venkat, Thomas Varghese, Singh Shivaram Prasad, Chandak Giriraj Ratan

Abstract excerpt

OBJECTIVE: Association of PRSS1-PRSS2 (rs10273639) and CLDN2-MORC4 (rs12688220 and rs7057398) variants with alcohol-related chronic pancreatitis (CP) is established but with nonalcoholic CP is unclear. We addressed this inconsistency using tropical calcific pancreatitis (TCP) as model. METHODS: We sequenced 5'-UTR of PRSS1 and genotyped CLDN2-MORC4 variants in 555 patients with TCP and 801 controls and performed...

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Source

Identifiers

PMID: 26784911
DOI: 10.1097/MPA.0000000000000608

Genes

CLDN2
MORC4
PRSS1
PRSS2
SPINK1
CTSB

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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