Article

Adrenomedullin Restores Mitochondrial Bioenergetics and Rescues Interneuron Phenotypes in Human Models of 22q11.2 Deletion Syndrome

2026-05-24

Abstract excerpt

<h4>SUMMARY</h4> 22q11.2 deletion syndrome (22q11.2DS), also known as DiGeorge syndrome, is the strongest genetic risk factor for schizophrenia, yet the cellular mechanisms underlying this vulnerability remain incompletely understood. Using iPSC-derived human subpallial organoids (hSOs) and forebrain assembloids (hFAs), we identified key 22q11.2DS cellular and molecular phenotypes in migrating cortical interneuro...

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Literature Corpus work: 60d8e139-77b1-5937-a52b-f0b06ecf297a
DOI: 10.64898/2026.05.24.726075

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