Article

A multi-network approach to Alzheimer’s Disease gene prioritization complements <i>cis</i> -regulatory prioritization with molecular quantitative trait loci

2023-05-03

Abstract excerpt

Gene prioritization within mapped disease-risk loci from genome-wide association studies (GWAS) remains one of the central bioinformatic challenges of human genetics. This problem is abundantly clear in Alzheimer’s Disease (AD) which has several dozen risk loci, but no therapeutically effective drug target. Dominant strategies emphasize alignment between molecular quantitative trait loci (mQTLs) and disease risk l...

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Literature Corpus work: 60d5de15-c2a3-5f06-8048-c70028d3bf23
DOI: 10.1101/2023.05.03.539189

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