Article

An empirical Bayes framework for burden and dispersion association tests helps prioritize rare variants associated with Alzheimer’s disease

2026-06-25

Abstract excerpt

Rare genetic variants provide critical insight into the mechanisms underlying complex diseases, yet their study is limited by inherent statistical challenges, particularly in the noncoding genome where functional prioritization remains difficult. Here, we introduce parmigiano , an empirical Bayesian framework that systematically integrates functional annotations into existing rare variant association tests (RVATs...

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Literature Corpus work: 335ea0bd-221a-53a8-883e-89155f058fe7
DOI: 10.64898/2026.06.15.26354742

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