Article

Biochemical and metabolic maladaption defines pathological niches in progressive multiple sclerosis

2022-09-27

Abstract excerpt

Progressive multiple sclerosis (MS) is driven by demyelination, neuroaxonal loss, and mitochondrial damage occurring behind a closed blood-brain barrier (BBB). 1,2 Patients with progressive MS typically fail to respond to available immunomodulatory drugs that reduce relapses in early disease. 2 This indicates a dire need to identify non-canonical therapeutic avenues to limit neurodegeneration and promote protect...

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Literature Corpus work: 60cb3974-97b3-58e7-8b8e-bd4fda57fc08
DOI: 10.1101/2022.09.26.509462

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