Article

Induced Degradation of Lineage-specific Oncoproteins Drives the Selective PARP1 Inhibitor Toxicity in Small Cell Lung Cancer

2022-11-03

Abstract excerpt

A subset of small cell lung cancer (SCLC) shows clinically relevant response to PARP1 inhibitors (PARPi). However, BRCA1/2 mutations are not commonly found in SCLC, and the underlying mechanism(s) of PARPi sensitivity in SCLC is poorly understood. We performed quantitative proteomic analyses and identified proteomic changes that signify PARPi responses in a large panel of molecularly annotated patient-derived SCL...

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Literature Corpus work: 427867e0-1449-5889-a154-145e3a4f97d4
DOI: 10.1101/2022.11.02.514072

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