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Article

All-In-One Dendrimer-Based Lipid Nanoparticles Enable Precise HDR-Mediated Gene Editing In Vivo.

Advanced materials (Deerfield Beach, Fla.) - 1 Jul 2021

Farbiak Lukas, Cheng Qiang, Wei Tuo, Álvarez-Benedicto Ester, Johnson Lindsay T, Lee Sang, Siegwart Daniel J

Abstract excerpt

Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) protein gene editing is poised to transform the treatment of genetic diseases. However, limited progress has been made toward precise editing of DNA via homology-directed repair (HDR) that requires careful orchestration of complex steps. Herein, dendrimer-based lipid nanoparticles (dLNPs) are engineered to co-encapsulate and...

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Identifiers

PMID: 34137093
DOI: 10.1002/adma.202006619
PMCID: PMC10041668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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