Article

Uncovering novel mutational signatures by <i>de novo</i> extraction with SigProfilerExtractor

2020-12-13

Abstract excerpt

<h4>SUMMARY</h4> Mutational signature analysis is commonly performed in genomic studies surveying cancer and normal somatic tissues. Here we present SigProfilerExtractor, an automated tool for accurate de novo extraction of mutational signatures for all types of somatic mutations. Benchmarking with a total of 34 distinct scenarios encompassing 2,500 simulated signatures operative in more than 60,000 unique synth...

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Literature Corpus work: 6098aa99-bf12-59df-a885-5dd51e794b6b
DOI: 10.1101/2020.12.13.422570

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