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A Glioma Stem Cell–Associated Transcriptomic Program Predicts Survival Across Adult and Pediatric High-Grade Gliomas

2025-10-17

Abstract excerpt

High-grade gliomas (HGGs), including adult glioblastoma (GBM) and pediatric diffuse intrinsic pontine gliomas (DIPGs), are sustained by glioma stem cells (GSCs) that drive tumor initiation, therapeutic resistance, and recurrence. Although numerous prognostic models have been proposed, few are directly grounded in the core biology of GSCs across both adult and pediatric HGGs. In this study, we defined a GSC-associa...

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Literature Corpus work
cdde599f-241d-52ce-b493-79e07402f6cc
DOI
10.1101/2025.10.15.25338073
Open publication

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A Glioma Stem Cell–Associated Transcriptomic Program Predicts Survival Across Adult and Pediatric High-Grade GliomasDOI 10.1101/2025.10.15.25338073
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