Article

Multi-omics of sorafenib responsiveness in HCC patients

2025-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Tumor response rates to targeted therapy are generally low. This poses an urgent medical need to identify molecular mechanisms determining responsiveness to inform therapy. We describe the first longitudinal deepscale multi-omic analysis (genomics, transcriptomics, proteomics and phosphoproteomics) of tumor biopsies from eight hepatocellular carcinoma (HCC) patients treated with the targeted kin...

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Literature Corpus work: 5ff32e04-5b0f-502b-81ae-48a059d05532
DOI: 10.1101/2025.07.15.25331324

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