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Article

CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content.

The Journal of cell biology - 6 Sept 2010

Craige Branch, Tsao Che-Chia, Diener Dennis R, Hou Yuqing, Lechtreck Karl-Ferdinand, Rosenbaum Joel L, Witman George B

Abstract excerpt

Mutations in human CEP290 cause cilia-related disorders that range in severity from isolated blindness to perinatal lethality. Here, we describe a Chlamydomonas reinhardtii mutant in which most of the CEP290 gene is deleted. Immunoelectron microscopy indicated that CEP290 is located in the flagel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20819941
DOI: 10.1083/jcb.201006105
PMCID: PMC2935561

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20819941-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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CEP290 tethers flagellar transition zone microtubules to the membrane and regulates flagellar protein content.PMID 20819941Read ↗

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