Article

nanoCLAMP potently neutralizes SARS-CoV-2 and protects K18-hACE2 mice from infection

2023-04-03

Abstract excerpt

Intranasal treatments, combined with vaccination, has the potential to slow mutational evolution of virusues by reducing transmission and replication. Here we illustrate the development of a SARS-CoV-2 receptor binding domain (RBD) nanoCLAMP and demonstrate its potential as an intranasally administered therapeutic. A multi-epitope nanoCLAMP was made by fusing a pM affinity single-domain nanoCLAMP (P2710) to altern...

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Literature Corpus work: 5fdf4a2e-7b39-5cda-92eb-cc0b9c82b8bf
DOI: 10.1101/2023.04.03.535401

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