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Article

Insights into SARS-CoV-2's Mutations for Evading Human Antibodies: Sacrifice and Survival.

Journal of medicinal chemistry - 24 Feb 2022

Luan Binquan, Huynh Tien

Abstract excerpt

The highly infectious SARS-CoV-2 variant B.1.351 that first emerged in South Africa with triple mutations (N501Y, K417N, and E484K) is globally worrisome. It is known that N501Y and E484K can enhance binding between the coronavirus receptor domain (RBD) and human ACE2. However, the K417N mutation appears to be unfavorable as it removes one interfacial salt bridge. Here, we show that despite the decrease in...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33834772
DOI: 10.1021/acs.jmedchem.1c00311

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