Article
Genetic liability to age at first sex and birth in relation to cardiovascular diseases: a Mendelian randomization study.
BMC medical genomics - 6 Apr 2023
Chen Miao, Wang Zhen, Xu Hongfei, Chen Xiaofang, Teng Peng, Ma Liang
Abstract excerpt
BACKGROUND: Growing evidence suggests that various reproductive factors, including early menarche, early menopause, and age at first birth, may increase the risk of developing cardiovascular disease (CVD) later in life. However, the associations between reproductive factors and CVDs are inconsistent and controversial. Therefore, we conducted a two-sample Mendelian randomization (MR) analysis to explore the...
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