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Article

Natural menopause, menarche and breast cancer risk in BRCA1 and BRCA2 pathogenic variant carriers: a Mendelian randomization analysis.

British journal of cancer - 1 May 2026

Mavaddat Nasim, Barnes Daniel R, Michailidou Kyriaki, Zhao Emily, Frost Debra, Leslie Goska, Dennis Joe, Wang Qin, Bolla Manjeet K, Evans D Gareth, Tischkowitz Marc, Thompson Deborah J, Perry John R B, Antoniou Antonis C, Easton Douglas F

Abstract excerpt

BACKGROUND: The influence of age at menarche (AAM) and age at natural menopause (ANM) on breast cancer (BC) risk in BRCA1 and BRCA2 germline pathogenic variant (PV) carriers is uncertain. Observational studies are prone to bias and have limited statistical power. Mendelian randomization (MR) minimises bias and may be used to examine causal effects. METHODS: Two-sample and age-specific MR analyses for BC were...

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Identifiers

PMID: 41912676
DOI: 10.1038/s41416-026-03365-6
PMCID: PMC13133355

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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