Article

Ultra-fast and highly sensitive protein structure alignment with segment-level representations and block-sparse optimization

2025-03-16

Abstract excerpt

Deep learning models for protein structure prediction have given rise to extreme growth in 3D structure data. As a result, traditional methods for geometric structure alignment are too slow to effectively search modern structure libraries. In this study we introduce SPfast – a fully geometric method for structure-based alignment which accelerates search by more than 2 orders of magnitude while increasing sensitivi...

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Identifiers and source

Literature Corpus work: 5fb61faa-7477-59c9-8a37-9a2c79adb301
DOI: 10.1101/2025.03.14.643159

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