Article

LinearTurboFold: Linear-Time Global Prediction of Conserved Structures for RNA Homologs with Applications to SARS-CoV-2

2020-11-24

Abstract excerpt

The constant emergence of COVID-19 variants reduces the effectiveness of existing vaccines and test kits. Therefore, it is critical to identify conserved structures in SARS-CoV-2 genomes as potential targets for variant-proof diagnostics and therapeutics. However, the algorithms to predict these conserved structures, which simultaneously fold and align multiple RNA homologs, scale at best cubically with sequence l...

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Literature Corpus work: 2fc63cb6-c3d2-5fbb-9add-3adf91a47d02
DOI: 10.1101/2020.11.23.393488

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