Back to search

Article

Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer

2026-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Serous endometrial cancer (SEC) is an aggressive subtype of endometrial cancer (EC) with poor prognosis and limited treatment options. Here, we developed a clinically relevant, immunocompetent serous-like mouse model incorporating oncogenic PIK3CA mutation, Trp53 loss, and MYC overexpression. Using this model together with human EC cell lines, patient-derived organoids (PDOs), xenografts, and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5faf5aa8-e4b1-5d5d-a7d4-5a5cabcd5216
DOI
10.64898/2026.02.16.706009
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancerDOI 10.64898/2026.02.16.706009
Dissecting endometrial cancer complexity in response to standard and targeted therapiesSemantic proximity
A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities.Semantic proximity
Immune microenvironment and molecular mechanisms in endometrial cancer: implications for resistance and innovative treatmentsSemantic proximity
Integrated Patient-Derived Xenograft and Patient-Derived Cell Models Reveal Therapeutic Vulnerabilities Beyond Standard-of-Care Therapy in Endometrial CancerSemantic proximity
Murine Xenograft Models as Preclinical Tools in Endometrial Cancer ResearchSemantic proximity
LATS1/2 Loss Promote Tumor Immune Evasion in Endometrial Cancer through Downregulating MHC-I ExpressionSemantic proximity
Modeling High-grade serous ovarian carcinoma using a combination of <i>in vivo</i> electroporation and CRISPR/Cas9 mediated genome editingSemantic proximity
Modeling High-Grade Serous Ovarian Carcinoma Using a Combination of In Vivo Fallopian Tube Electroporation and CRISPR-Cas9-Mediated Genome Editing.Semantic proximity
Systematic Growth Factor Profiling Platform for 3D Tumor Models Reveals Estradiol-Responsive Cellular Mechanisms of Immunotherapy ResistanceSemantic proximity
IL1β/IL1R1/IRAK4 Drives Inflammatory Ovarian Cancer Seeding at the inflamed sites and Is Reversed by an IRAK4 inhibitor UR241-2Semantic proximity
The Spatial Immune Landscape of Mismatch Repair Deficient Endometrial Cancer: Implications for Clinical OutcomesSemantic proximity
CRISPR/Cas9-Mediated <i>Trp53</i> and <i>Brca2</i> Knockout to Generate Improved Murine Models of Ovarian High-Grade Serous CarcinomaSemantic proximity
Select a neighboring publication to make it the new centre.