Article

Transcriptomic profiling of Early-onset sporadic Alzheimer’s disease patients

2022-06-17

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) manifested before 65 years of age is commonly referred to as early-onset AD (EOAD) [1]. Significant research on EOAD has focused on autosomal-dominant familial mutations in <italic>PSEN1</italic>, <italic>PSEN2</italic>, and <italic>APP</italic>; however, these mutations only represent 5–10% of EOAD cases. Although EOAD has a higher heritability (92–100%) than s...

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Literature Corpus work: 5fa46641-5667-595a-a5be-c87ff424a43e
DOI: 10.21203/rs.3.rs-1766592/v1

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