Article
[Genetic architecture of amyotrophic lateral sclerosis and frontotemporal dementia : Overlap and differences].
Der Nervenarzt - 1 Jul 2017
Synofzik M, Otto M, Ludolph A, Weishaupt J H
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) overlap not only clinically, but also with respect to shared neuropathology and genes. A large number of novel genes has recently been identified which underlie both diseases, e. g., C9orf72, TARDBP, GRN, TBK1, UBQLN2, VCP, CHCHD10, or SQSTM1. In contrast, other genes are still largely associated with only one of the two diseases, e. g., SOD1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.