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Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses

19 Jun 2022

Abstract excerpt

Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human, bat, and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the set of inhibitors correlated with antiviral activity and genetic knockdown confirmed the essential role of the CSNK2 holoenzyme in β-coronavirus replication....

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PMID: 35723434
DOI: 10.1021/acschembio.2c00378

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