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NAMPT INHIBITION SELECTIVELY TARGETS MDS MYELOBLASTS IN HIGH-RISK MDS WITH MONOSOMY 7 OR DEL(7Q)

2025-09-15

Abstract excerpt

Monosomy 7 and deletion of the q arm of chromosome 7 (-7/-7q) are high-risk markers in myelodysplastic syndromes (MDS). We previously showed that blasts with -7/-7q from patients with acute myeloid leukemia (AML) are exceptionally sensitive to NAMPT inhibitors, with the sensitivity caused by NAMPT gene haploinsufficiency as a result of - 7/-7q. The objective of this study was to investigate whether blasts from pat...

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Literature Corpus work
cd16e11b-17da-51e1-b08b-415d29e068ce
DOI
10.1101/2025.09.14.25335622
Open publication

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NAMPT INHIBITION SELECTIVELY TARGETS MDS MYELOBLASTS IN HIGH-RISK MDS WITH MONOSOMY 7 OR DEL(7Q)DOI 10.1101/2025.09.14.25335622
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