Article
Impact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7.
Leukemia - 1 Sept 2020
Crisà Elena, Kulasekararaj Austin G, Adema Vera, Such Esperanza, Schanz Julie, Haase Detlef, Shirneshan Katayoon, Best Steven, Mian Syed A, Kizilors Aytug, Cervera José, Lea Nicholas, Ferrero Dario, Germing Ulrich, Hildebrandt Barbara, Martínez Ana Belén Valencia, Santini Valeria, Sanz Guillermo F, Solé Francesc, Mufti Ghulam J
Abstract excerpt
Monosomy 7 [-7] and/or partial loss of chromosome 7 [del(7q)] are associated with poor and intermediate prognosis, respectively, in myelodysplastic syndromes (MDS), but somatic mutations may also play a key complementary role. We analyzed the impact on the outcomes of deep targeted mutational screening in 280 MDS patients with -7/del(7q) as isolated cytogenetic abnormality (86 with del(7q) and 194 with -7)....
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