Article

Adaptive Regularized Tri-Factor Non-Negative Matrix Factorization for Cell Type Deconvolution

2023-12-08

Abstract excerpt

Accurate deconvolution of cell types from bulk gene expression is crucial for understanding cellular compositions and uncovering cell-type specific differential expression and physiological states of diseased tissues. Existing deconvolution methods have limitations, such as requiring complete cellular gene expression signatures or neglecting partial biological information. Moreover, these methods often overlook va...

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Literature Corpus work: 5f535d5a-4e23-5643-9928-82518df24962
DOI: 10.1101/2023.12.07.570631

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