Article
SimiC enables the inference of complex gene regulatory dynamics across cell phenotypes.
Communications biology - 12 Apr 2022
Peng Jianhao, Serrano Guillermo, Traniello Ian M, Calleja-Cervantes Maria E, Chembazhi Ullas V, Bangru Sushant, Ezponda Teresa, Rodriguez-Madoz Juan Roberto, Kalsotra Auinash, Prosper Felipe, Ochoa Idoia, Hernaez Mikel
Abstract excerpt
Single-cell RNA-Sequencing has the potential to provide deep biological insights by revealing complex regulatory interactions across diverse cell phenotypes at single-cell resolution. However, current single-cell gene regulatory network inference methods produce a single regulatory network per input dataset, limiting their capability to uncover complex regulatory relationships across related cell phenotypes. We...
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