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Article

Eupatilin rescues ciliary transition zone defects to ameliorate ciliopathy-related phenotypes.

The Journal of clinical investigation - 1 Aug 2018

Kim Yong Joon, Kim Sungsoo, Jung Yooju, Jung Eunji, Kwon Ho Jeong, Kim Joon

Abstract excerpt

Ciliopathies are clinically overlapping genetic disorders involving structural and functional abnormalities of cilia. Currently, there are no small-molecule drugs available to treat ciliary defects in ciliopathies. Our phenotype-based screen identified the flavonoid eupatilin and its analogs as lead compounds for developing ciliopathy medication. CEP290, a gene mutated in several ciliopathies, encodes a protein...

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Identifiers

PMID: 30035750
DOI: 10.1172/JCI99232
PMCID: PMC6063470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Eupatilin rescues ciliary transition zone defects to ameliorate ciliopathy-related phenotypes.PMID 30035750Read ↗

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