Article

Pharmacological cAMP stimulation via prostaglandin receptors rescues ciliary defects in CEP290-deficient human and mouse models

2023-10-06

Abstract excerpt

<h4>ABSTRACT</h4> The retina’s sensitivity to light depends on the primary cilium of photoreceptors, known as the outer segment (OS). OS defects are a primary cause of inherited retinal dystrophies (IRDs) and can also indicate wider ciliary dysfunctions. One such IRD is Leber congenital amaurosis type 10 (LCA10), which occurs as a monosymptomatic retinal disease or the presenting symptom of syndromic ciliopathies...

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Literature Corpus work: a9d74d0a-33cf-5ded-b8b5-255898d2a662
DOI: 10.1101/2023.10.06.561156

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