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Article

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.

Stem cell reports - 10 Apr 2018

Deng Wen-Li, Gao Mei-Ling, Lei Xin-Lan, Lv Ji-Neng, Zhao Huan, He Kai-Wen, Xia Xi-Xi, Li Ling-Yun, Chen Yu-Chen, Li Yan-Ping, Pan Deng, Xue Tian, Jin Zi-Bing

Abstract excerpt

Retinitis pigmentosa (RP) is an irreversible, inherited retinopathy in which early-onset nyctalopia is observed. Despite the genetic heterogeneity of RP, RPGR mutations are the most common causes of this disease. Here, we generated induced pluripotent stem cells (iPSCs) from three RP patients with different frameshift mutations in the RPGR gene, which were then differentiated into retinal pigment epithelium (RPE)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29526738
DOI: 10.1016/j.stemcr.2018.02.003
PMCID: PMC5998840

Genes

RPGR
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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