Article

High-throughput prediction of MHC Class I and Class II neoantigens with MHCnuggets

2019-08-31

Abstract excerpt

Computational prediction of binding between neoantigen peptides and major histocompatibility complex (MHC) proteins is an emerging biomarker for predicting patient response to cancer immunotherapy. Current neoantigen predictors focus on in silico estimation of MHC binding affinity and are limited by low positive predictive value for actual peptide presentation, inadequate support for rare MHC alleles and poor sca...

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Literature Corpus work: 95f92955-8fa8-5ac3-afd4-386cffd51a37
DOI: 10.1101/752469

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