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Article

Impaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy.

Journal of the American Heart Association - 19 Mar 2024

Wang Renjie, Hasegawa Moyu, Suginobe Hidehiro, Yoshihara Chika, Ishii Yoichiro, Ueyama Atsuko, Ueda Kazutoshi, Hashimoto Kazuhisa, Hirose Masaki, Ishii Ryo, Narita Jun, Watanabe Takuji, Kawamura Takuji, Taira Masaki, Ueno Takayoshi, Miyagawa Shigeru, Ishida Hidekazu

Abstract excerpt

BACKGROUND: Restrictive cardiomyopathy (RCM) is characterized by impaired diastolic function with preserved ventricular contraction. Several pathogenic variants in sarcomere genes, including TNNI3, are reported to cause Ca2+ hypersensitivity in cardiomyocytes in overexpression models; however, the pathophysiology of induced pluripotent stem cell (iPSC)-derived cardiomyocytes specific to a patient with RCM remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38497452
DOI: 10.1161/JAHA.123.032375
PMCID: PMC11010001

Genes

TNNI3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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