Article

PI3Kβ inhibition restores ALK inhibitor sensitivity in ALK-rearranged lung cancer

2021-03-18

Abstract excerpt

<h4>ABSTRACT</h4> For non-small cell lung cancer (NSCLC) patients with ALK -rearranged tumors, treatment with ALK inhibitors can improve outcomes. However, clinical resistance typically develops over time, and in the majority of cases resistance mechanisms are ALK-independent. We generated tumor cell cultures from multiple regions of an ALK -rearranged clinical tumor specimen, and deployed functional drug scree...

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Literature Corpus work: 5e510df8-4e8c-5204-bcd0-58e62aefe1d6
DOI: 10.1101/2021.03.18.435801

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