Article
Patient-derived models of acquired resistance can identify effective drug combinations for cancer.
Science (New York, N.Y.) - 19 Dec 2014
Crystal Adam S, Shaw Alice T, Sequist Lecia V, Friboulet Luc, Niederst Matthew J, Lockerman Elizabeth L, Frias Rosa L, Gainor Justin F, Amzallag Arnaud, Greninger Patricia, Lee Dana, Kalsy Anuj, Gomez-Caraballo Maria, Elamine Leila, Howe Emily, Hur Wooyoung, Lifshits Eugene, Robinson Hayley E, Katayama Ryohei, Faber Anthony C, Awad Mark M, Ramaswamy Sridhar, Mino-Kenudson Mari, Iafrate A John, Benes Cyril H, Engelman Jeffrey A
Abstract excerpt
Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here, we describe a pharmacogenomic platform that facilitates rapid discovery of drug combinations that can overcome resistance. We established cell culture models derived from biopsy samples of lung cancer patients whose disease had progressed while on treatment with epidermal growth factor...
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