Article

Association between anti-interferon-alpha autoantibodies and COVID-19 in systemic lupus erythematosus

2020-11-03

Abstract excerpt

<h4>Objectives</h4> Anti-type I interferon (IFN) autoantibodies have been reported in patients with systemic lupus erythematosus (SLE). Recently, an association of these autoantibodies with severe COVID-19 was reported in the general population. We assessed whether having pre-existing anti-IFNα autoantibodies was associated with COVID-19 infection in SLE patients. <h4>Methods</h4> Patients with SLE who developed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5e4af552-8213-5be2-8417-3a450fc341bf
DOI: 10.1101/2020.10.29.20222000

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Association between anti-interferon-alpha autoantibodies and COVID-19 in systemic lupus erythematosusDOI 10.1101/2020.10.29.20222000Read

Multi-omics analysis uncovered systemic lupus erythematosus and COVID-19 crosstalkSemantic proximity Read

Abnormalities of the type I interferon signaling pathway in lupus autoimmunity.Semantic proximity Read

Interferon alpha as a primary pathogenic factor in human lupus.Semantic proximity Read

Optimal Selection of IFN-α-Inducible Genes to Determine Type I Interferon Signature Improves the Diagnosis of Systemic Lupus ErythematosusSemantic proximity Read

Suppression of Type I Interferon Signaling in Myeloid Cells by Autoantibodies in Severe COVID-19 PatientsSemantic proximity Read

Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients.Semantic proximity Read

Featured immune characteristics of COVID-19 and systemic lupus erythematosus revealed by multidimensional integrated analysesSemantic proximity Read

Heterozygous RELA mutations cause early-onset systemic lupus erythematosus by hijacking the NF-κB pathway towards transcriptional activation of type-I Interferon genesSemantic proximity Read

Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19Semantic proximity Read

Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo.Semantic proximity Read

IFN-associated B cell hyperactivity is highly enriched in SLE patients harboring Sm/RNP antibodiesSemantic proximity Read

Interferon-alpha: a therapeutic target in systemic lupus erythematosus.Semantic proximity Read